The younger brother of Anthony Dirrell, Andre Dirrell began boxing while still in elementary school, trained by their grandfather, a former sparring partner of Muhammad Ali. During his time as an amateur, Dirrell won the 2003 United States National Amateur Championships at middleweight, won a bronze medal at the 2004 Olympic Games at middleweight, and competed at the 2003 Pan American Games.
Dirrell made his pro debut on Jan. 27, 2005. Dirrell was undefeated for 18 straight bouts before suffering his first loss as a pro. After a six-fight win streak, Dirrell challenged James DeGale for the IBF Super Middleweight Championship on May 23, 2015, but lost the bout via decision.
Dirrell won the interim IBF Super Middleweight Championship on May 20, 2017, via disqualification.